The topic of this paper is exploring the intersection of art and psychology with the impact of artistic creation on the mental health of college students. After reviewing previous literature on art and psychology, the theoretical basis of art therapy, the relationship between artistic creation and psychological process, this paper takes college students as the research object to explore the impact of artistic creation on their mental health. Through literature review, empirical investigation and concrete case analysis, this paper analyzes the positive and negative effects of artistic creation on college students’ mental health and its mechanism. The main arguments of this paper includes: 1) Mental health status of college students; 2) The concrete influence of art elements on the psychology of college students. The research shows that artistic creation, as a form of creative expression, is helpful to improve college students’ self-cognition, emotional regulation, psychological anti-pressure ability and social communication ability to promote their mental health development.