Restraining the non-small cell lung cancer (NSCLC) tumor by usingMART 10, a vitamin D analog and E-Cadherin

Abstract

NSCLC is one of the most common types of cancer. Previous studies have reported that MART 10 has been affecting
anaplastic thyroid cancer, indicating a decrease in the tumor after the injection of MART 10. Since previous studies
rarely investigate the effect of MART 10 within the NSCLC, this study investigates the effect of MART 10 in the
NSCLC, both in vivo and in vitro methods. The study will use A549 cell lines, with negative control PBS and positive
control EGFR inhibitors or increasing MART 10—various methods, both in vitro, such as MTT, western blot, and
wound healing assay. In vivo, such as A549 mice xenografts, the paper investigates whether or not MART 10 can
restrain the development of NSCLC tumors.