2DG Affects Liver Cancer Cell Ferroptosis By Affecting

Abstract

Cancer cells are characterized by high proliferation but at the expense of enhanced metabolic rates. If the active
oxygen content in the cell exceeds the average level, cancer cells activate antioxidant defenses against this increase.
Ferroptosis occurs when glutathione levels are reduced due to a lack of cysteine in the cell. Ferroptosis is a new type of
asymptomatic apoptosis. We chose to investigate the sensitivity of cancer cells to the effect of 2DG on ferroptosis. These
include some effects of 2DG on intracellular NADPH solubility and NADPH’s role in converting cystine to cysteine in
cancer cells. The effect of cysteine on glutathione, the inhibitory effect of glutathione on ROS in cancer cells, and the
accumulation of ROS can lead to ferroptosis in cancer cells.