Transgenerational Epigenetic Inheritance Through miR-212/132 Expression Alterations Induced by Environmental Stress

Abstract

Transgenerational epigenetic inheritance studies suggest that environmental stress can have lasting effects across generations. It proposes the hypothesis that the expression changes of miRNA-212/132 induced by environmental stress will lead to transgenerational epigenetic inheritance. The validity of this hypothesis is demonstrated through experimental behavior changes, RNA expression differences, nucleotide change experiments, and qRT-PCR analysis, and the influence of environmental stress between generations is confirmed again. This will facilitate the application of relevant practical aspects in the future.