Environmental Stress Drives Transgenerational Epigenetic Inheritance Through miR-212/132 Expression Upregulation

Abstract

This is a research proposal on environmental induced transgenerational epigenetic inheritance. This work focus on pressure on food supply lead to a modification in miR-212/132 expression that result in an increased feeding of mice, and is inherited by the transfer of the miRNAs from hippocampus to sperm. Experiments including behavior tests, miRNA differential expression, gene knock-out, and nucleotide modification are proposed to prove the hypothesis. Once carried out, the research is going to help expand the understanding of transgenerational epigenetic inheritance, explore the cause of inherited obesity susceptibility, and contribute to public health.