Iron ion and siramesine-loaded polydopamine nanoparticles forenhanced breast cancer therapy

Abstract

Ferroptosis is a novel type of nonapoptotic cell death, showing a hopeful potential in cancer therapeutic schedules. One
of the apparent features of ferroptosis is the lipid hydroperoxides producing ROS induced by intracellular iron ions
accumulation. Thus the iron regulation and metabolism in the cell is an essential factors for the trigger of ferroptosis.
We designed a new nanoparticle that loaded ferric ions and siamese based on polydopamine nanomaterial (siramesine@
Fe(III) PDA NPs) to induce breast cancer ferroptosis through the Fenton reaction. Iron ions can be added to cancer cells,
and siamese can block the exportation of intracellular iron by inhibiting the expression of FPN, thus promoting the
Fenton reaction. The extra transport of iron ions into cells by nanoparticles and the inhibition of iron ions outward by
Siramesine promoted the accumulation of iron ions in cells, thus achieving a synergistic effect leading to ferroptosis in
cells. In addition, NPs demonstrated excellent pH-responsive degradation, with enhanced drug release at the pH value
of tumor microenvironments and lysosomal. Siramesine@Fe(III) PDA NPs showed good ferroptosis induction ability,
displaying the potential for cancer treatment.