Effects of Increased Adult Hippocampal Neurogenesis on Neuronal Output from the Subiculum to the Lateral Hippocampus under Anxiety

Abstract

Numerous studies assessed the important involvement of adult hippocampal neurogenesis (AHN) in the regulation of stress. Although the precise processes underlying the promotion of AHN on the recovery of anxiety-induced symptoms have been thoroughly examined, they are still unclear.We observed the subiculum region and its neuronal output to the lateral hippocampal formation, which may serve as a conduit between AHN and the recovery from depression.In order to cultivate AHN with exercise and fluoxetine injection independently, we employed a mouse model. We then used FosTRAP2, PET, and fMRI to measure the subiculum’s neural activity during anxiety.When considered collectively, our findings imply that raising AHN in anxious mice modifies the way some subiculum neurons in the lateral hippocampal region output.