Primary liver cancer is one of the four leading causes of cancer death in humans, and the ethnic diversity and wide distribution of the affected population are very serious, so it is important to control the mortality rate of primary liver cancer patients worldwide. In order to control the global proportion of patients with liver cancer and reduce the mortality rate of primary liver cancer, it is necessary to identify the differences between ethnic groups and explore the impact of these differences on the prevalence of primary liver cancer. Diet and genes make Spain and blacks in Europe and the United States more susceptible to liver cancer, while the culture and lifestyle of Asia make people in Central Asia and Southeast Asia more susceptible to hepatitis virus infection and non-alcoholic hepatitis (NAFLD). The specific activation temperature of Aspergillus flavus causes it to secrete aflatoxins in tropical and subtropical regions, and its exposure to the toxin can carry HBV infection and increase liver cancer’s prevalence in local residents. Gender is also a main factor of liver cancer’s mortality differences, which is mostly due to the fact that men have a higher proportion of smoking, alcohol abuse and overweight. This means that in countries with a high proportion of men, such as the U.A.E., Qatar, the Philippines and other Southeast Asian regions, the prevalence and mortality of liver cancer will be higher.
