The inflammatory injury of microglia involved in Tourette syndrome development

Abstract

Tourette Syndrome (TS), a chronic neuroinflammatory disorder, is characterized by motor and vocal tics. Microglial inflammatory activity in TS is increased, while microglial-mediated clearance mechanisms are compromised. Our study aimed to investigate the effect of puerarin on microglial inflammation. Our study confirmed that 20 mg/mL of puerarin was the optimal intervention concentration by CCK8 analysis. Furthermore, we found that puerarin could inhibit proinflammatory factors and up-regulate anti-inflammatory factors at the protein and mRNA levels, thus playing a role in regulating microglial inflammation. This study provides a new strategy for regulating neuroinflammation in TS.