Inhibition of integrin receptor by increasing concentrations and treatment durations with Cilengitide increases the sensitivity of killing in vivo of U87 glioma cancer cell xenograft mouse.

Abstract

This study examined the effects of integrin αvβ3 on specific cell lines and xenograft mice. The experiment used female nude mice (BALB/c mice, four weeks old). The protein is collected in a lysis buffer containing phosphatase and protease inhibitors. Cell cycle distribution was measured by FACSCalibur flow cytometry, and MTT measures the activity of cells. The results of 12 combinations were described in this study. The results of this study indicated whether Cilengitide therapy can inhibit glioma proliferation in vitro and in vivo. To conclude, the results of this study also provided some insights into future research directions in the same field. The interaction mechanism between Cilengitide and gliomas can be further investigated to provide insights into the molecular pathways and may reveal additional therapeutic targets.