Down-Regulation of TRIM11 in Lysosomal Regulation: Investigating its Impact on Cellular Degradation Pathways

Abstract

Alzheimer’s disease is characterized by the accumulation of Aβ plaques and tau protein tangles, with TRIM11 playing a crucial role in tau regulation [1]. However, TRIM11’s degradation in Alzheimer’s remains unclear. This study investigates whether lysosomes, responsible for cellular degradation, are involved in TRIM11 degradation [2]. Lysosome inhibitors were applied, and TRIM11 levels were examined. Immunostaining for TRIM11 and lysosome inhibitors was conducted to assess co-localization, indicating potential interaction. The findings suggest a connection between TRIM11 and lysosomes in Alzheimer’s pathology, warranting further research for potential therapeutic implications [3].