Does the Glandular Tolerant to McL-1 Inhibitor S63845?

Abstract

MCL-1 is an anti-apoptotic protein that regulates cell apoptosis and has been observed in over-expression in many
cancer. It makes the MCL-1 an available target. S63845 is introduced to treat cancer, an inhibitor with a high affinity to
MCL-1. However, the tolerability of the human body to the treatment remains unanswered. Therefore in this paper, we
designed the experiment to test the tolerability of regular issue glandular with cancerous individuals of the same cell
line, the apoptosis will be tested by the MTT theory, and the direct production of inhibition --BAX will be measured
by western blot. The result is predicted, and this work will provide meaningful information for future cancer treatment.
Future studies should focus on cooperation with other BCL-2 inhibitors and the impact of the treatment.