A Possible Reward Prediction Error Circuit Exists in Brain: AroundPrefrontal Cortex and Ventral Tegmental Area

Abstract

This work aims to find a potential neuronal circuit from the Prefrontal cortex to the ventral tegmental area. In neurology,
previous research focuses on how signal transfers from the ventral tegmental area to the Prefrontal cortex. Theoretically,
the Prefrontal cortex is an effector and a processor. Therefore, a possible circuit, using the Prefrontal cortex as the
departure, could be designed to find. This work is designed to employ some techniques, floxed genes, neuronal virus
tracing, and an electrical detector in the brain to prove the desired circuit and give some prediction results. Those
results will prove whether the neuronal circuit existed or not. If the electrical signals from the PFC region to VTA can
be detected in termination, such a desired circuit is possible. This work may help to complete the learning mechanism,
reward prediction error system, physiologically.