Ochratoxin A (OTA) Affect OATPs and PEPTs and Cause RenalDisease

Abstract

Ochratoxin A (OTA) is a mycotoxin related to the kidneys. There is a consensus that the primary route in which OTA
is excreted into the urine is via tubular secretion, possibly through the organic anion transport system. There are some
kinds of multipiece organic anion-transporting polypeptides (OATPs), ATP-binding cassettes (ABC) transporters, and
transporters such as organic anion transporters (OATs). These renal transporters are essential in exacerbating OTAinduced nephrotoxicity as OTA penetrates the cell membrane. This work concluded that the renal tubule’s reabsorption
and secretion of OTA might play an essential role in OTA accumulation and nephrotoxicity. Also, it tells us it is essential
to consider the impact of albumin binding on transport in vitro when considering the clearance of OTA in vivo.