Research on Target Peptides and siRNA Delivery Systems in Lung Cancer Targeted Therapy

Abstract

With the development of gene silencing technology and siRNA, significant potential has been demonstrated in cancer treatment, garnering widespread attention. siRNA specifically targets and degrades certain mRNA, thereby inhibiting the expression of corresponding proteins. It has shown great promise in applications such as cancer, viral infections, and genetic diseases. However, the effective delivery of siRNA has been a major challenge for its clinical application. This paper focuses on discussing the mechanisms and advantages of siRNA delivery systems and introduces the current challenges and research issues faced by siRNA, such as the application mechanisms, dosage, and toxicity of targeted peptides and siRNA delivery systems.