With the outbreak of various influenza and viruses, there is a growing concern about the mode of transmission of bacteria and the means of sterilization. Since antimicrobial coatings can be applied to a variety of materials and equipment in the fields of medical devices, food packaging, waterproofing systems, etc., there are many existing research studies and designs on antimicrobial surfaces. However, there are still some unresolved issues in the practical application and production of the current research. The research of nanomaterials applied in the field of antimicrobials is a relatively new technology. This study is based on polyurethane coating composite nanomaterials as the topic, respectively. It summarizes the research on three aspects of nanometallic materials composite polyurethane coating, organic nanomaterials composite polyurethane antimicrobial coating, and quantum dots modified polyurethane nanocomposites, and proposes the relevant ideas for improvement.