Heisenberg’s uncertainty principle (HUP) is a central concept in quantum mechanics that reveals inherent limitations in the measurement of microscopic particles and profoundly affects the understanding of the physical world. This paper reviews the physical significance of HUP and its applications and research progress in modern physics. The complexity of measurements in quantum systems is revealed by deriving the uncertainty relation and analysing the wavefunction collapse and the classicalisation of quantum states. This paper summarises the current experimental verification of the principle of measurement uncertainty in different quantum systems and discusses the research progress in improving measurement accuracy through quantum entanglement. Recent studies have shown that controlling quantum entangled states can effectively reduce measurement disturbances and thus improve the measurement accuracy of quantum systems without violating the principle of mismeasurement. Despite the many advances made, there are still challenges to further improve the measurement accuracy in complex quantum systems. Future research will continue to explore the potential for applications in this area.